BMS 8702 Cancer Biology
This course will cover essential concepts in cancer pathogenesis, highlighting fundamental cellular regulatory processes that are subverted in cancer. We will build upon previous discussions of genome organization and apply these to understand the genomic abnormalities that drive cancer development, how they are identified, and new insights into disease classification driven by identification of molecular signatures. We will include historical examples of how oncogenes and tumor-suppressor genes were identified, integrated with discussion and analysis of current literature highlighting different model systems for cutting-edge analysis of the mechanistic consequences of cancer-associated mutations and signaling pathways of central importance in cancer. During this section, the Core Facilities Program will showcase state-of-the-art methods in monitoring tumor development in the Preclinical Imaging Core. Students will also engage in clinical shadowing during this section.